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短尾猴双侧玻璃体腔内注射雷珠单抗0.25mg/眼至2.0mg/眼的剂量范围,每2周一次,持续26周,出现剂量依赖的眼部影响。注射后2天,前房闪辉与细胞出现剂量依赖性增加并达到峰值。炎性反应的程度在随后注射治疗中或恢复期内通常减轻,但并未在所有病例中完全恢复。在眼后节,发生玻璃体浑浊,该症状同样有剂量依赖性倾向,且一般持续至治疗期结束。在26周的研究中,玻璃体炎症反应的严重程度随注射次数而增加。恢复期后观察到可逆的迹象。后节炎症的自然病程和持续时间显示这是免疫介导的抗体反应,没有临床相关性。在相对长期的严重炎症后,在一些动物中观察到白内障形成,提示晶状体的改变更可能是继发于严重的炎症。在玻璃体内注射药物后观察到眼内压出现短暂的升高,这一反应与剂量大小无关。眼组织的显微镜改变全部与炎症有关,没有显示有任何眼结构的变性过程。在有些眼的视神经盘中观察到肉芽肿炎性改变。这些后段的变化在恢复期中减轻,有些病例中完全消失。本品玻璃体内注射后未发现全身毒性特征。在部分接受给药的动物中发现血清和玻璃体内中有本品的抗体。尚无本品在动物中致癌、致突变和生殖毒性与发育毒性的数据。

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